rs3761548 (C/A) and rs5902434 (del/ATT) polymorphisms of Foxp3 gene in Iranian patients with migraine

Abstract Background Migraine is a neurovascular disorder; several studies have demonstrated the immune system plays key role in migraine pathogenesis . The aim of this study was to investigate association between FOXP3 gene polymorphism and susceptibility migraine. Methods In case–control study, 55 whole blood samples patients with 80 healthy were collected. After DNA extraction, genotyping rs5902434 ( del / ATT ) rs3761548 (C/A) performed using sequence-specific primers method (PCR-SSP). Results results showed that there statistically significant differences patient control group genotype frequencies addition, frequency heterozygous AC at found be significantly higher than controls. We also no cases controls allelic distribution (del/ATT) polymorphism. None genotypes any Conclusions According finding our associated Further larger sample sizes different populations other parts world are needed relationship on susceptibility.